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The London Osteoporosis Clinic offers innovative osteoporosis treatment. CoFounded by Dr Taher Mahmud, a prominent clinician and trustee of the Global Osteoporosis Foundation, this clinic has pioneered a multidisciplinary approach to osteoporosis management. This article delves into their unique perspective on bisphosphonates, which can be helpful, but there are better alternatives.

Introduction: A Holistic Approach

At the London Osteoporosis Clinic, the approach to treating osteoporosis is anything but one-dimensional. They believe in a holistic approach that combines non-drug interventions with carefully considered drug therapies. This combination ensures a comprehensive and tailored treatment plan for each patient.

The Role of Bisphosphonates

Bisphosphonates have emerged as the primary pharmacological intervention for the treatment of osteoporosis. As the first line of treatment in primary care and in most guidelines, they have demonstrated beneficial effects in enhancing bone density and reducing the risk of fractures. However, like all medications, they come with their own set of advantages and disadvantages.

The Pros of Bisphosphonates

One cannot deny the positive impact bisphosphonates have had in the treatment of osteoporosis. They are effective in increasing bone density and reducing the incidence of fractures, which is crucial for patients with fragile bones. These drugs work by inhibiting bone resorption, thereby preserving bone mass.

The Cons: Side Effects

While bisphosphonates offer significant benefits, they are not without their share of side effects. Common side effects include gastrointestinal issues like nausea and stomach pain. More severe side effects, such as jaw osteonecrosis and atypical fractures, have been reported in rare cases.

The Need for Close Supervision

Given the potential side effects, the London Osteoporosis Clinic emphasises the need for close supervision when patients are on bisphosphonate therapy. Regular monitoring and follow-up appointments are crucial to address any emerging complications promptly.

Mandatory Review After Five Years

One unique aspect of their approach is the mandatory review of patients who have been on bisphosphonates for over five years. This careful consideration is rooted in the understanding that long-term use may necessitate adjustments to the treatment plan. It ensures that the patient’s health and well-being remain the top priority.


In conclusion, the London Osteoporosis Clinic’s approach to bisphosphonate use in osteoporosis treatment is a testament to their commitment to patient care. Their multidisciplinary approach and the judicious use of drugs and better alternatives to bisphosphonates exist, but if they are used, the patients need to be reviewed regularly.


  1. What are bisphosphonates, and how do they work? Bisphosphonates are a class of drugs used to treat osteoporosis by inhibiting bone resorption, thereby increasing bone density.
  2. What are the common side effects of bisphosphonates? Common side effects include gastrointestinal discomfort, such as nausea and stomach pain.
  3. Why is close supervision necessary for bisphosphonate therapy? Close supervision is essential to monitor and address any potential side effects or complications that may arise during treatment.
  4. What is the significance of mandatory reviews after five years of bisphosphonate use? Mandatory reviews ensure that long-term users of bisphosphonates receive appropriate adjustments to their treatment plans, prioritizing their health.
  5. How can I access the services of the London Osteoporosis Clinic? To access the clinic’s services, please visit for more information.

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